Previous research from this laboratory has demonstrated that the environmental circumstances surrounding amphetamine administration can powerfully modulate both its acute psychomotor activating effects and the ability of repeated amphetamine to induce behavioral sensitization. The purpose of the experiments described in this proposal is to examine, using immediate early gene expression as a marker of neuronal activity, the neural systems involved in the environmental modulation of both the acute and repeated effects of amphetamine. Specifically, we hypothesize that 1) the neural circuitry engaged by acute amphetamine will vary as a function of the environment in which it is administered, 2) the neural circuitry engaged by amphetamine will change as a function of prior drug history and the development of sensitization, and these neuroadaptations will vary as a function of the environment in which drug is administered, and 3) that mere exposure to contextual stimuli associated with prior drug administration will engage similar neural circuitry as that engaged by exposure to the drug itself. These experiments will provide important new insights into how the neurobiological actions of amphetamine are modulated by the environmental circumstances surrounding its administration.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31DA005905-03
Application #
6175068
Study Section
Special Emphasis Panel (ZDA1-MXS-M (09))
Program Officer
Babecki, Beth
Project Start
2000-09-01
Project End
Budget Start
2000-09-01
Budget End
2001-12-31
Support Year
3
Fiscal Year
2000
Total Cost
$24,313
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109