The proposed research will investigate the hypothesis that smoking enables trait-anhedonic people to experience pleasure in situations that commonly invoke positive moods among those without trait-anhedonia. This premise will be tested by evaluating changes in positive moods in trait-anhedonic people vs. non trait-anhedonic people after exposure to the following conditions: a positive mood induction while smoking, a positive mood induction while not smoking, and a neutral mood induction while smoking. It is hypothesized that trait-anhedonic people will only be responsive to a positive mood induction if they are allowed to smoke. In other words, it is expected that trait-anhedonic smokers will require the pharmacologic effect of nicotine in combination with a pleasurable psychological stimulus to experience a degree of positive mood elevation that nonanhedonics experience without smoking. Positive mood will be measured via self-report. This study will be the first to examine the effect of smoking on a trait-anhedonic person's ability to experience pleasure. Results will enhance understanding of mechanisms that promote smoking among those with pleasure deficits, and may contribute to the development of smoking cessation treatments and other substance control interventions for people with chronic difficulties experiencing pleasure.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31DA014144-03
Application #
6634360
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
2002-04-11
Project End
Budget Start
2003-04-11
Budget End
2004-04-10
Support Year
3
Fiscal Year
2003
Total Cost
$33,796
Indirect Cost
Name
University of Illinois at Chicago
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
McChargue, Dennis E; Werth Cook, Jessica (2007) Depression vulnerability within smoking research: How accurate are one-item screening items? Addict Behav 32:404-9
Cook, Jessica Werth; Spring, Bonnie; McChargue, Dennis (2007) Influence of nicotine on positive affect in anhedonic smokers. Psychopharmacology (Berl) 192:87-95
Doran, Neal; McChargue, Dennis; Spring, Bonnie et al. (2006) Effect of nicotine on negative affect among more impulsive smokers. Exp Clin Psychopharmacol 14:287-95
McChargue, Dennis E; Cohen, Lee M; Cook, Jessica W (2004) Attachment and depression differentially influence nicotine dependence among male and female undergraduates: a preliminary study. J Am Coll Health 53:5-10
McChargue, Dennis; Cohen, Lee; Cook, Jessica Werth (2004) The influence of personality and affect on nicotine dependence among male college students. Nicotine Tob Res 6:287-94
Cook, Jessica Werth; Spring, Bonnie; McChargue, Dennis et al. (2004) Hedonic capacity, cigarette craving, and diminished positive mood. Nicotine Tob Res 6:39-47
Cook, Jessica Werth; Spring, Bonnie; McChargue, Dennis E et al. (2004) Influence of fluoxetine on positive and negative affect in a clinic-based smoking cessation trial. Psychopharmacology (Berl) 173:153-9
McChargue, Dennis E; Spring, Bonnie; Cook, Jessica W et al. (2004) Reinforcement expectations explain the relationship between depressive history and smoking status in college students. Addict Behav 29:991-4