? It is reported that humans addicted to drugs of abuse fail to respond appropriately to natural rewards like food, employment, and caring for their children. Similarly, we have shown that rats with a greater propensity to self-administer drugs of abuse also avoid intake of a natural gustatory reward after it is repeatedly paired with the opportunity to self-administer the drug reward. Under our reward comparison hypothesis, avoidance of the natural reward results from devaluation of the taste cue as it comes to predict the availability of the more rewarding drug of abuse. As such, our model will not only allow for an assessment of cue-induced craving and relapse, as do other models, but also of the behavioral (Specific Aim I), environmental (Specific Aim II), and neurophysiological (Specific Aim Ill) factors underlying drug-induced devaluation of natural rewards. ? ? ? ?
| Twining, Robert C; Bolan, Matthew; Grigson, Patricia S (2009) Yoked delivery of cocaine is aversive and protects against the motivation for drug in rats. Behav Neurosci 123:913-25 |
| Wheeler, Robert A; Twining, Robert C; Jones, Joshua L et al. (2008) Behavioral and electrophysiological indices of negative affect predict cocaine self-administration. Neuron 57:774-85 |
| Bruno, Kristy J; Freet, Christopher S; Twining, Robert C et al. (2007) Abnormal latent inhibition and impulsivity in coloboma mice, a model of ADHD. Neurobiol Dis 25:206-16 |
| Hajnal, Andras; Acharya, Nikhil K; Grigson, Patricia S et al. (2007) Obese OLETF rats exhibit increased operant performance for palatable sucrose solutions and differential sensitivity to D2 receptor antagonism. Am J Physiol Regul Integr Comp Physiol 293:R1846-54 |
| Schroy, Pearl Lee; Wheeler, Robert A; Davidson, Collin et al. (2005) Role of gustatory thalamus in anticipation and comparison of rewards over time in rats. Am J Physiol Regul Integr Comp Physiol 288:R966-80 |
