Abstract

This application proposes to assess the effects of ambient temperature and thyroid hormone levels on the reinforcing effects of 3,4-methylenedioxymethamphetamine (MDMA) in a non-human primate model of drug abuse through methods of intravenous self-administration and in vivo microdialysis. We will compare the reinforcing and hyperthermic effects of self-administered MDMA using a concurrent choice procedure at ambient temperatures of 22 degrees C and 28 degrees C. Also, central dopamine release induced by MDMA within the ventral striatum will be assesed at the previous two ambient temperatures. Finally, the effects of chronic thyroxine treatment on MDMA-induced central dopamine release, hyperthermia and selfadministration will also be evaluated. This proposal aims to elucidate potential mechanisms involved in the reinforcing effects of MDMA and provide a more thorough understanding of the effects of thyroid hormone and ambient temperature on MDMA abuse. Understanding the behavioral and neurochemical mechanisms involved in MDMA-induced reinforcement will allow for increased public awareness and better pharmacotherapies for the toxicities associated with MDMA abuse.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31DA020281-02
Application #
7117263
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Lawrence, Diane M
Project Start
2005-08-22
Project End
2007-05-21
Budget Start
2006-08-22
Budget End
2007-05-21
Support Year
2
Fiscal Year
2006
Total Cost
$20,060
Indirect Cost

  Institution

Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157

  Publications

Gould, Robert W; Gage, H Donald; Banks, Matthew L et al. (2011) Differential effects of cocaine and MDMA self-administration on cortical serotonin transporter availability in monkeys. Neuropharmacology 61:245-51
Banks, Matthew L; Sprague, Jon E; Czoty, Paul W et al. (2008) Effects of ambient temperature on the relative reinforcing strength of MDMA using a choice procedure in monkeys. Psychopharmacology (Berl) 196:63-70
Banks, Matthew L; Czoty, Paul W; Gage, H Donald et al. (2008) Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys. Neuropsychopharmacology 33:219-25
Banks, Matthew L; Czoty, Paul W; Sprague, Jon E et al. (2008) Influence of thyroid hormones on 3,4-methylenedioxymethamphetamine-induced thermogenesis and reinforcing strength in monkeys. Behav Pharmacol 19:167-70
Banks, Matthew L; Gould, Robert W; Czoty, Paul W et al. (2008) Relationship between response rates and measures of reinforcing strength using a choice procedure in monkeys. Behav Pharmacol 19:365-9
Sikoski, P; Banks, M L; Gould, R et al. (2007) Comparison of rectal and infrared thermometry for obtaining body temperature in cynomolgus macaques (Macaca fascicularis). J Med Primatol 36:381-4
Banks, Matthew L; Czoty, Paul W; Nader, Michael A (2007) The influence of reinforcing effects of cocaine on cocaine-induced increases in extinguished responding in cynomolgus monkeys. Psychopharmacology (Berl) 192:449-56
Banks, Matthew L; Sprague, Jon E; Kisor, David F et al. (2007) Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys. Drug Metab Dispos 35:1840-5