Previous research on tolerance to effects of cocaine on operant behavior in rats and monkeys has revealed tolerance contingent on whether the drug is given pre or post session. A recently published experiment with pigeons, and the preliminary study did not find that tolerance was similarly contingent on when the drug was administered. The proposed research will further examine the role of behavioral factors and pharmacological factors in the development of tolerance to cocaine in pigeons through three experiments. Experiment 1 will examine the contributions of eating while under the effects of cocaine to the development of tolerance to cocaine during a preceding operant behavioral session. Experiment 2 will examine effects of mere drug exposure without exposure to a behavioral session in the development of tolerance to cocaine during a behavioral session. Experiment 3 will examine effects of acute and chronic cocaine administration on the pharmacokinetics of cocaine. This program of research will examine the role of behavioral factors, including the experimental session and eating, and pharmacological factors in the development of tolerance to behavioral effects of cocaine in pigeons. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31DA021452-01A1
Application #
7219854
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
2007-05-16
Project End
2009-05-15
Budget Start
2007-05-16
Budget End
2008-05-15
Support Year
1
Fiscal Year
2007
Total Cost
$30,707
Indirect Cost
Name
University of Florida
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Marusich, Julie A; Branch, Marc N (2009) Environmental and pharmacological factors in the development of noncontingent tolerance to cocaine in pigeons. Exp Clin Psychopharmacol 17:266-82
Marusich, Julie A; Branch, Marc N; Dallery, Jesse (2008) Limitations to the generality of cocaine locomotor sensitization. Exp Clin Psychopharmacol 16:282-92