Chemosensory signals activate brain regions along the vomeronasal and main olfactory pathways. In male hamsters, socially relevant chemosignals.from the same species of animal (conspecific) activate the anterior medal amygdala (MeA) and the posterior medialamygdala (MeP) and do not activate theGABATergic intercalated nucleus (ICN). Socially non-relevant chemosignals from other species activate MeA and ICN, but fail to activate MeP. Oxytocin knockout mice (OTKO) fail to recognize a conspecific that they have encountered previously. The cFos patterns in the medial amygdala suggest a heterospecific-like response to the stimulus animal. Therefore it is possible that oxytocin (OT) mediates the signal from the vomeronasal system in the medial amygdala allowing for """"""""downstream"""""""" continuation of the signal. These and other data suggest that oxytocin (OT) may affect medial amygdala responses to socially-relevant and socially non- relevant stimuli differently. This proposal will investigate OT effects in medial amygdala in response to conspecific and heterospecific chemosensory stimulation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31DC008062-02
Application #
7174278
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Cyr, Janet
Project Start
2006-01-01
Project End
2008-12-31
Budget Start
2007-01-01
Budget End
2007-12-31
Support Year
2
Fiscal Year
2007
Total Cost
$31,835
Indirect Cost
Name
Florida State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
790877419
City
Tallahassee
State
FL
Country
United States
Zip Code
32306