The preparation and evaluation of a new type of chiral oxazaborolane reduction catalyst is proposed. The new approach utilizes a simple and selective one-pot conversion of optically active beta-azido alcohols to these catalysts, a process facilitated by the special reactivity of the 9-borabicyclo[3.3.1]onane(9-BBN) ring system. These catalyst offer potential advantages over existing systems with respect to their ease of preparation, potential versatility and stability. Representatives prochiral ketones will be systematically examined in asymmetric reduction process using borane and these catalysts in both stoichiometric and catalytic amounts to assess the efficacy of these new systems for pharmaceutical and natural product applications.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31GM018030-03
Application #
2637914
Study Section
Special Emphasis Panel (ZRG3-MEDB (02))
Project Start
1998-01-01
Project End
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Puerto Rico Rio Piedras
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
San Juan
State
PR
Country
United States
Zip Code
00931