Abstract

Development of a novel, generic, biocompatible fusogenic carrier of antitumor agents that can be triggered to rapidly release its contents by two stimuli and to different activation apply this system to site- specific delivery of encapsulated material at biological targets is the goal of this proposal. The experiments described involve the syntheses and physical characterization of compounds that are aimed at optimizing the efficiency of liposomal photorelease and liposome-cell fusion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31GM018546-04
Application #
6018311
Study Section
Minority Programs Review Committee (MPRC)
Project Start
1999-08-12
Project End
Budget Start
1999-08-12
Budget End
2000-12-11
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Romero, Diego; Vlamakis, Hera; Losick, Richard et al. (2014) Functional analysis of the accessory protein TapA in Bacillus subtilis amyloid fiber assembly. J Bacteriol 196:1505-13
Chai, Liraz; Romero, Diego; Kayatekin, Can et al. (2013) Isolation, characterization, and aggregation of a structured bacterial matrix precursor. J Biol Chem 288:17559-68
Beauregard, Pascale B; Chai, Yunrong; Vlamakis, Hera et al. (2013) Bacillus subtilis biofilm induction by plant polysaccharides. Proc Natl Acad Sci U S A 110:E1621-30
Vlamakis, Hera; Chai, Yunrong; Beauregard, Pascale et al. (2013) Sticking together: building a biofilm the Bacillus subtilis way. Nat Rev Microbiol 11:157-68
Chai, Yunrong; Beauregard, Pascale B; Vlamakis, Hera et al. (2012) Galactose metabolism plays a crucial role in biofilm formation by Bacillus subtilis. MBio 3:e00184-12
Hochbaum, Allon I; Kolodkin-Gal, Ilana; Foulston, Lucy et al. (2011) Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development. J Bacteriol 193:5616-22
Romero, Diego; Vlamakis, Hera; Losick, Richard et al. (2011) An accessory protein required for anchoring and assembly of amyloid fibres in B. subtilis biofilms. Mol Microbiol 80:1155-68
Chai, Yunrong; Norman, Thomas; Kolter, Roberto et al. (2011) Evidence that metabolism and chromosome copy number control mutually exclusive cell fates in Bacillus subtilis. EMBO J 30:1402-13
Kolodkin-Gal, Ilana; Romero, Diego; Cao, Shugeng et al. (2010) D-amino acids trigger biofilm disassembly. Science 328:627-9
Chai, Yunrong; Kolter, Roberto; Losick, Richard (2010) Reversal of an epigenetic switch governing cell chaining in Bacillus subtilis by protein instability. Mol Microbiol 78:218-29

Showing the most recent 10 out of 16 publications