The goal of the research proposed here is to evaluate and quantify any changes resulting in the strength of the adhesive interactions between hard bioadhesive erodible polymer microspheres and living tissue when groups capable of Hydrogen bonding (e.g. OH, NH2, COOH) are chemically incorporated into the structure of the polymers. It has been shown that sufficient quantities of functional groups capable of Hydrogen bonding can lead to enhanced adhesive interactions for both hydrogels and other hydrophilic polymers and hard bioerodible thermoplastic polymers.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31GM020096-02
Application #
6179280
Study Section
Special Emphasis Panel (ZRG1-ALTX-4 (02))
Program Officer
Toliver, Adolphus
Project Start
2000-08-30
Project End
Budget Start
2000-08-30
Budget End
2001-08-29
Support Year
2
Fiscal Year
2000
Total Cost
$36,176
Indirect Cost
Name
Brown University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912