My primary research interests fall in the realm of cellular and molecular biology. From work I did studying X-inactivation I am excited about the therapeutic potential of transcriptional silencing, for example the potential for silencing proto-oncogenes as a treatment for cancer. As a result I have been interested in the mechanisms by which genes are regulated. For example, how the interaction between DNA and the nucleosome is affected by post-translational modifications. Since doing work with ataxia-telangeictasia (AT) I have become interested in how gene regulation is influenced by extra-cellular signals and environmental factors. Instead of looking at the biochemical changes that occur in the DNA and associated proteins, I have become more interested in looking at the pathways that result in biochemical changes. Ultimately, I want to study the dynamic nature of our genome. DNA does not just sit dily in the nucleus, but is actively involved in the maintenance of homeostasis. I want to understand the coordinated regulation of genes at the genome level. The sequenced genome offers many avenues for new approaches to medical treatment and medical research. As a clinically trained researcher I hope to bridge the gap between DNA sequence and patient care.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31GM066367-05
Application #
7115912
Study Section
Special Emphasis Panel (ZRG1-F05 (29))
Program Officer
Gaillard, Shawn R
Project Start
2002-09-01
Project End
2007-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
5
Fiscal Year
2006
Total Cost
$46,850
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104