The proposal describes current studies towards increasing the functional group tolerance of metal-catalyzed reactions of cyclohexylsilacyclopropane. Specific objectives that I intend to address are: to develop new siliranes from allylic ethers containing an adjacent stereocenter, to study the diastereoselectivity of these unreadily available siliranes in silacyclopropanation reactions, to understand the reaction mechanisms by which they proceed, and to expand the reactions of silacyclopropanes to synthetic applications. With the knowledge obtained from allylic ethers, I intend to extend the reaction to allylic epoxides. This would allow me to generate an oxasilacyclohexene derivative that can also be further functionalized. Other functionalities such as imines will be evaluated as well and the silaaziridines generated will also be explored as potential intermediates for organic synthesis. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31GM070391-03
Application #
7106442
Study Section
Special Emphasis Panel (ZRG1-CDF-1 (29))
Program Officer
Toliver, Adolphus
Project Start
2004-08-30
Project End
2007-07-30
Budget Start
2006-08-30
Budget End
2007-07-30
Support Year
3
Fiscal Year
2006
Total Cost
$28,739
Indirect Cost
Name
University of California Irvine
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697