Genomic integrity is crucial for an organism's survival. Surveillance mechanisms ensure that the genome is properly replicated and faithfully transmitted from a cell to its daughters. If the integrity of the genome is compromised, a checkpoint mechanism is activated to delay cell cycle progression until the aberration is repaired. In particular, the DNA replication checkpoint delays progression into mitosis until the DNA has been accurately and fully replicated. While some components of the checkpoint mechanism are known, many of the elements involved in the events underlying the checkpoint response have not been characterized or are not fully understood. Using an in vitro expression cloning strategy (IVEC) to screen a Xenopus oocyte cDNA library, we wish to identify novel components and interactions involved in the DNA replication checkpoint to provide a better understanding of this vital process. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31GM072087-02
Application #
7033822
Study Section
Special Emphasis Panel (ZRG1-F05 (29))
Program Officer
Gaillard, Shawn R
Project Start
2005-09-30
Project End
2006-09-30
Budget Start
2005-10-01
Budget End
2006-09-30
Support Year
2
Fiscal Year
2006
Total Cost
$39,923
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
009584210
City
Pasadena
State
CA
Country
United States
Zip Code
91125