Abstract

The current proposal entails an investigation of some of the consequences of oxidative stress in yeast, with particular focus on aspects of mitochondrial dysfunction. The genetic approach central to this examination will allow for an unambiguous definition of cytochrome c peroxidase (CCP1) as part of the antioxidant defenses of the cell and the role it plays in conjunction with copper-zinc superoxide dismutase (SOD1).
Specific Aim 1 : Define the biological role of CCP1 The first specific aim of this study will address the issue of definitively characterizing the functional role of CCP1 as an antioxidant enzyme.
Specific Aim 2 : Evaluate the functional link between SOD1 and CCP1 The second specific aim of this study will investigate the potential existence and nature of a functional link between Ccplp and the ubiquitous antioxidant enzyme, Sodlp. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31GM077083-02
Application #
7222695
Study Section
Special Emphasis Panel (ZRG1-GGG-G (29))
Program Officer
Toliver, Adolphus
Project Start
2006-07-01
Project End
2009-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
2
Fiscal Year
2007
Total Cost
$30,074
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Li, Alice Ma; Martins, Jake; Tovmasyan, Artak et al. (2014) Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae. Redox Biol 3:1-6
Sehati, Sadaf; Clement, Matthew H S; Martins, Jake et al. (2011) Metabolic alterations in yeast lacking copper-zinc superoxide dismutase. Free Radic Biol Med 50:1591-8