The proposed study will examine several issues pertaining to the effect of behavioral stress on cardiovascular and pain regulatory systems and their possible interaction in healthy men and women with depressed mood but without major depression or any chronic pain disorder. Measures of thermal and ischemic pain sensitivity will be assessed at baseline and after a 5- minute stress (stress day) or rest (control day) period. Systolic and diastolic blood pressure, heart rate., impedance-derived estimates of stroke volume, cardiac output, and total peripheral resistance, and beta- endorphin and catecholamine levels will be measured during baseline, rest and stress periods, and accompanying pain measurement. A major goal is to extend my previous findings relating stress-induced analgesia to blood pressure reactivity to stress in normotensive humans. The study's results may have implications for models of psychophysiological mechanisms contributing to the development of cardiovascular disease, and for the experience of anginal pain versus painless (silent) myocardial ischemia in patients with coronary heart disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH011404-03
Application #
2674532
Study Section
Health Behavior and Prevention Review Committee (HBPR)
Program Officer
Altman, Fred
Project Start
1998-08-01
Project End
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Costello, Nancy L; Bragdon, Edith E; Light, Kathleen C et al. (2002) Temporomandibular disorder and optimism: relationships to ischemic pain sensitivity and interleukin-6. Pain 100:99-110
Bragdon, Edith E; Light, Kathleen C; Costello, Nancy L et al. (2002) Group differences in pain modulation: pain-free women compared to pain-free men and to women with TMD. Pain 96:227-37