Many higher order cognitive functions that plan, regulate, and monitor behavior have been neglected by the community of cognitive psychologists. We intend to address this shortcoming by determining the behavioral nature and neural implementation of one such function, which we call error processing, in humans. It has been demonstrated that activation of an error detection system manifests itself at the scalp as a negative deflection in the event-related brain potential (ERP). Preliminary evidence suggested that this error-detection system is mediated, at least in part, by the anterior cingulate gyrus. The primary goal now is to confirm that error-related activity occurs in the anterior cingulate by employing functional neuroimaging techniques such as ERPs and magnetoencephalograms (MEG), and by the development of a biologically plausible computational model of anterior cingulate dynamics. A secondary goal is to distinguish, using ERPs, between behaviors that activate and behaviors that do not activate the error detection system. This research is expected to elucidate the nature of several clinical disorders, including Obsessive-Compulsive Disorder and various psychopathologies associated with lesions of the frontal lobes.
|Holroyd, Clay B; Coles, Michael G H (2008) Dorsal anterior cingulate cortex integrates reinforcement history to guide voluntary behavior. Cortex 44:548-59|
|Holroyd, Clay B; Yeung, Nick; Coles, Michael G H et al. (2005) A mechanism for error detection in speeded response time tasks. J Exp Psychol Gen 134:163-91|
|Miltner, Wolfgang H R; Lemke, Ulrike; Weiss, Thomas et al. (2003) Implementation of error-processing in the human anterior cingulate cortex: a source analysis of the magnetic equivalent of the error-related negativity. Biol Psychol 64:157-66|
|Holroyd, Clay B; Coles, Michael G H (2002) The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Psychol Rev 109:679-709|
|Holroyd, Clay B; Praamstra, Peter; Plat, Erik et al. (2002) Spared error-related potentials in mild to moderate Parkinson's disease. Neuropsychologia 40:2116-24|
|Coles, M G; Scheffers, M K; Holroyd, C B (2001) Why is there an ERN/Ne on correct trials? Response representations, stimulus-related components, and the theory of error-processing. Biol Psychol 56:173-89|
|Holroyd, C B; Dien, J; Coles, M G (1998) Error-related scalp potentials elicited by hand and foot movements: evidence for an output-independent error-processing system in humans. Neurosci Lett 242:65-8|