Memory deficits in schizophrenia are pervasive, and considered by some to be a cardinal feature of the illness. However, little is known about the neural mechanisms associated with these deficits. This project will investigate the functional neural circuitry involved in memory processing by recording EEG from patients with schizophrenia during a visual memory task. By using a delayed match-to-sample paradigm that has been shown to activate spatially distinct regions of the brain in animal studies, precise timing of stimulus encoding, memory maintenance and recognition stages of memory processing will be distinguished with both well-characterized ERPs and recently developed dynamic techniques such as phase and power across time. These methods allow 1) investigation of the role of synchronized neural activity associated with each stage of memory function, 2) examination of the relationships between each stage, 3) determination of the relationships between EEG activity and performance. The strength of this study lies in the incorporation of different levels of analyses to investigate the functional neural activity associated with memory deficits in schizophrenia. Characterizing this activity will lead to a better understanding of the functional circuitry inherent to the disorder and how this dysfunctional system translates into aberrant behavior. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH068933-02
Application #
6805651
Study Section
Special Emphasis Panel (ZRG1-BBBP-5 (01))
Program Officer
Desmond, Nancy L
Project Start
2003-09-18
Project End
2004-10-17
Budget Start
2004-09-18
Budget End
2004-10-17
Support Year
2
Fiscal Year
2004
Total Cost
$2,490
Indirect Cost
Name
Indiana University Bloomington
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Brenner, Colleen A; Edwards, Chad R; Carroll, Christine A et al. (2004) P50 and acoustic startle gating are not related in healthy participants. Psychophysiology 41:702-8