The proposed study aims to gain a better understanding of the etiology of impulsivity and its relationship to antisocial behavior in children within the context of an extensive behavioral, cognitive, and psychophysiological assessment battery. The study will expand on previous findings by also investigating the genetics of impulsivity during a laboratory paradigm, the Go/NoGo task. Performance measures of response latency (reaction times) and number of errors will be obtained and calculated during the task. An existing hypothesis states that faster reaction times and shorter latencies are indicative of impulsive responding. Subjects will include 600 pairs of 9 and 10-year old twins and their primary caregivers recruited from the Los Angeles county school districts. The study will be conducted in a genetically informative twin design, which will allow for the investigation of the genetic and environmental influences of impulsivity. Multivariate genetic analyses will also be employed to examine possible genetic and environmental influences of motor and behavioral impulsivity during the Go/NoGo task.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH068953-03
Application #
7194970
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Ferrell, Courtney
Project Start
2005-03-14
Project End
2008-02-13
Budget Start
2007-03-14
Budget End
2008-02-13
Support Year
3
Fiscal Year
2007
Total Cost
$42,112
Indirect Cost
Name
University of Southern California
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Bezdjian, Serena; Baker, Laura A; Tuvblad, Catherine (2011) Genetic and environmental influences on impulsivity: a meta-analysis of twin, family and adoption studies. Clin Psychol Rev 31:1209-23
Bezdjian, S; Raine, A; Baker, L A et al. (2011) Psychopathic personality in children: genetic and environmental contributions. Psychol Med 41:589-600
Bezdjian, Serena; Tuvblad, Catherine; Raine, Adrian et al. (2011) The genetic and environmental covariation among psychopathic personality traits, and reactive and proactive aggression in childhood. Child Dev 82:1267-81
Isen, Joshua; Raine, Adrian; Baker, Laura et al. (2010) Sex-specific association between psychopathic traits and electrodermal reactivity in children. J Abnorm Psychol 119:216-25
Bezdjian, Serena; Baker, Laura A; Lozano, Dora Isabel et al. (2009) Assessing inattention and impulsivity in children during the Go/NoGo task. Br J Dev Psychol 27:365-83
Isen, Joshua D; Baker, Laura A; Raine, Adrian et al. (2009) Genetic and environmental influences on the junior temperament and character inventory in a preadolescent twin sample. Behav Genet 39:36-47