Abstract

Long-term Goals: 1. To advance my knowledge of preserved versus impaired cognitive functions in schizophrenia, and how they relate to the psychiatric manifestations of the disorder. 2. To learn to conduct research in cognitive neuroscience using high resolution spatiotemporal imaging, including rapid presentation, event-related fMRI and MEG. 3. To become proficient in design, implementation and data analysis of combined fMRI/MEG projects.
Specific Aims : I. In healthy subjects, to identify the spatiotemporal patterns of activation associated with a) intact inhibition, b) inhibition errors, and c) error processing using rapid-presentation, event-related fMRI and MEG. II. In schizophrenia, to identify the stages at which inhibition is abnormal and error processing is intact with regard to the location, timing, and magnitude of neural activation using rapid-presentation, event-related fMRI and MEG.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH072120-02
Application #
6946340
Study Section
Special Emphasis Panel (ZRG1-F01 (20))
Program Officer
Ferrell, Courtney
Project Start
2004-08-04
Project End
2006-08-03
Budget Start
2005-08-04
Budget End
2006-08-03
Support Year
2
Fiscal Year
2005
Total Cost
$21,774
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Polli, Frida E; Wright, Christopher I; Milad, Mohammed R et al. (2009) Hemispheric differences in amygdala contributions to response monitoring. Neuroreport 20:398-402
Polli, Frida E; Barton, Jason J S; Thakkar, Katharine N et al. (2008) Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia. Brain 131:971-86
Thakkar, Katharine N; Polli, Frida E; Joseph, Robert M et al. (2008) Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD). Brain 131:2464-78
Manoach, Dara S; Thakkar, Katherine N; Cain, Matthew S et al. (2007) Neural activity is modulated by trial history: a functional magnetic resonance imaging study of the effects of a previous antisaccade. J Neurosci 27:1791-8
Polli, Frida E; Barton, Jason J S; Vangel, Mark et al. (2006) Schizophrenia patients show intact immediate error-related performance adjustments on an antisaccade task. Schizophr Res 82:191-201
Polli, Frida E; Barton, Jason J S; Cain, Matthew S et al. (2005) Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission. Proc Natl Acad Sci U S A 102:15700-5