Recent studies suggest that adult subgranular zone (SGZ) neurogenesis is required for hippocampal plasticity and antidepressant (AD) efficacy. As such, psychiatric research would greatly benefit from understanding the relationship between AD and SGZ neurogenesis. However, fundamental questions about neurogenesis remain unanswered, particularly in regards to the ability of AD to increase SGZ neurogenesis.
Three specific aims are proposed 1: Determine how changes in cell cycle kinetics, progenitor division and survival contribute to AD-induced increase in the number of proliferating SGZ cells. 2: Characterize the differential response to AD of the cell types which contribute to the heterogeneous population of dividing cells in the SGZ. 3: Evaluate the potential of proliferating cells in SGZ to respond directly to BDNF. Analysis of the relationship between AD and neurogenesis will provide much needed insight into how SGZ proliferating cells are regulated. These proposed studies will not only provide important information about AD action - crucial for developing new drugs and understanding depression - but also will provide insight into how adult neurogenesis is regulated - a critical issue for biomedical science as a whole. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31MH075457-01A1
Application #
7112807
Study Section
Special Emphasis Panel (ZRG1-F03A-M (20))
Program Officer
Curvey, Mary F
Project Start
2006-04-01
Project End
2008-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
1
Fiscal Year
2006
Total Cost
$29,723
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390