Histories of major depressive disorder (MDD) are more prevalent in Premenstrual Dysphoric Disorder (PMDD), and both disorders are associated with greater daily stress and somatic symptoms. We will compare PMDD (N=26) and non-PMDD women (N=26), with or without a history of MDD (N=13 per each MDD x PMDD group), for experimental pain sensitivity and biological responses to stress in order to examine biological factors contributing to somatic symptoms in these disorders. This study will examine sympathetic and hypothalamic-pituitary-adrenal (HPA) axis responses to stress, experimental and daily pain ratings, as well as the relationship between biological pain regulatory mechanisms, (e.g. blood pressure) and experimental pain sensitivity in the luteal phase of the menstrual cycle. Testing will involve 3 components: 1) Daily ratings of mood and somatic symptoms; 2) Experimental pain sensitivity to ischemic forearm pain; 3) Blood pressure, heart rate, and plasma norepinephrine, cortisol, and beta-endorphins at rest and in response to mental stress. The results of this study will provide insight into stress responsive biological factors that may contribute to heightened pain in both PMDD and MDD, and may confirm other evidence for persistent stress dysregulation in currently euthymic women with prior MDD. MDD affects approximately 25 percent of women in their lifetime, while PMDD affects 5-8 percent of women in their reproductive years. The impact of PMDD on quality of life is equivalent to that seen in MDD and other psychiatric disorders. Studies designed to address biological factors involved in the somatic symptoms of both MDD and PMDD may have implications for treatment of these disorders. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH079532-02
Application #
7481101
Study Section
Special Emphasis Panel (ZRG1-F12B-J (20))
Program Officer
Rubio, Mercedes
Project Start
2007-07-23
Project End
2010-07-22
Budget Start
2008-07-23
Budget End
2009-07-22
Support Year
2
Fiscal Year
2008
Total Cost
$29,291
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Psychiatry
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Klatzkin, Rebecca R; Mechlin, Beth; Girdler, Susan S (2010) Menstrual cycle phase does not influence gender differences in experimental pain sensitivity. Eur J Pain 14:77-82
Klatzkin, Rebecca R; Lindgren, Monica E; Forneris, Catherine A et al. (2010) Histories of major depression and premenstrual dysphoric disorder: Evidence for phenotypic differences. Biol Psychol 84:235-47