Type I diabetic women face the constant challenge of trying to maintain normal blood glucose levels to avoid the long-term complications of diabetes. Menstrual cycle changes during the luteal phase may contribute to fluctuations in glucose levels but definitive recommendations for adjustments of insulin dosage are not available due to conflicting experimental data. Some studies suggest that premenstrual syndrome (PMS) may exacerbate menstrual cycle changes in insulin sensitivity. Proposed Study I is designed to determine if there are differences in insulin sensitivity between the two phases of the menstrual cycle in Type I diabetic women with and without PMS. Diabetics may be particularly susceptible to PMS since previous studies suggest that PMS is related to low serotonin levels and diabetes itself may lead to low serotonin levels. Selective serotonin re-uptake inhibitors (SSRI's) have been used to successfully treat PMS in nondiabetic populations. In Type 2 obese diabetics, SSRI's have been shown to have a glucose-lowering effect, independent of weight loss. To date, no study has examined the use of SSRI's for the treatment of PMS in diabetic women. Study 2 will examine the effects of an SSRI on insulin sensitivity and PMS symptoms in Type I diabetic women with PMS. Insulin sensitivity will be measured using the frequently sampled intravenous glucose tolerance test.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NR008179-01
Application #
6551758
Study Section
National Institute of Nursing Research Initial Review Group (NRRC)
Program Officer
Armstrong, Nell
Project Start
2002-09-01
Project End
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
1
Fiscal Year
2002
Total Cost
$27,612
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Nursing
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Trout, Kimberly K; Homko, Carol; Tkacs, Nancy C (2007) Methods of measuring insulin sensitivity. Biol Res Nurs 8:305-18
Trout, Kimberly K; Rickels, Michael R; Schutta, Mark H et al. (2007) Menstrual cycle effects on insulin sensitivity in women with type 1 diabetes: a pilot study. Diabetes Technol Ther 9:176-82
Trout, Kimberly K; Teff, Karen L (2004) Insulin sensitivity and premenstrual syndrome. Curr Diab Rep 4:273-80
Trout, Kimberly K (2004) The neuromatrix theory of pain: implications for selected nonpharmacologic methods of pain relief for labor. J Midwifery Womens Health 49:482-8