Patient-ventilator synchrony is critical in achieving optimal oxygenation and ventilation. However, ventilator synchrony is difficult to quantify. Nurses often asses patient-ventilator dysnchrony (PVD) using a non-empirical approach, and clinical manifestations of dysychrony are not standardized. Identifying valid biobehavioral measures of this phenomenon will assist clinicians to reduce the complications of mechanical ventilation. Thus, the specific aims of this fellowship are to: 1) Identify biobehavioral markers (physiologic stability, agitation and patient behavior) of patient-ventilator dysnchrony and 2) Examine the effect of patient ventilator dysynchrony on the use of sedation. Patient ventilator dysynchrony will be identified using changes in airway pressure waveforms that will be obtained continuously over a 24-hour period. The bio-behavioral markers of patient-ventilator dysynchrony to be evaluated in this study will include physiologic instability (heart rate, SaO2, respiratory rate), agitation (actigraphy) and direct observation of patient behaviors as well as amount of sedation use. Describing PVD will assist clinicians in early and accurate detection of dysynchrony, which may lead to reduction in risks associated with mechanical ventilation and sedation. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NR009623-01A1
Application #
7112511
Study Section
National Institute of Nursing Research Initial Review Group (NRRC)
Program Officer
Huss, Karen
Project Start
2006-04-15
Project End
2009-04-14
Budget Start
2006-04-15
Budget End
2007-04-14
Support Year
1
Fiscal Year
2006
Total Cost
$33,300
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
Schools of Nursing
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Mellott, Karen G; Grap, Mary Jo; Munro, Cindy L et al. (2014) Patient ventilator asynchrony in critically ill adults: frequency and types. Heart Lung 43:231-43
Mellott, Karen G; Grap, Mary Jo; Munro, Cindy L et al. (2009) Patient-ventilator dyssynchrony: clinical significance and implications for practice. Crit Care Nurse 29:41-55 quiz 1 p following 55
Unoki, Takeshi; Grap, Mary Jo; Sessler, Curtis N et al. (2009) Autonomic nervous system function and depth of sedation in adults receiving mechanical ventilation. Am J Crit Care 18:42-50; quiz 51
Mellott, Karen G; Sharp, Pamela B; Anderson, Lynn M (2008) Biobehavioral measures in a critical-care healing environment. J Holist Nurs 26:128-35;quiz 136-8