Management of the side effects of antiretroviral therapy (ART) has become a primary focus in the treatment of human immunodeficiency virus (HlV)-infected individuals. Among the most pervasive of these side effects are the metabolic complications. As more women are infected with HIV, and as HIV/AIDS becomes a chronic disease rather than a lethal diagnosis, more of these women will be looking for ways to have families and space pregnancies, rather than to terminate their ability to reproduce. However, despite research in the general literature that points to significant metabolic dysregulation with contraceptive use, especially in areas that overlap with the side effects seen in HIV and its treatment, no research has yet examined whether or not contraceptive hormone use contributes to HIV-infected women's risk for metabolic complications. A secondary data analysis of the Women's Interagency HIV Study (WIHS) cohort is proposed as an initial step towards investigating this problem. The training plan is designed to provide the informational background and research experience necessary to allow the trainee to carry out the research plan. The sponsors will contribute their expertise in HIV/AIDS, metabolic dysregulation, and research methodology. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NR009886-02
Application #
7226305
Study Section
Special Emphasis Panel (ZNR1-REV-J (94))
Program Officer
Jett, Kathleen
Project Start
2006-05-01
Project End
2008-05-31
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
2
Fiscal Year
2007
Total Cost
$41,636
Indirect Cost
Name
Yale University
Department
Type
Schools of Nursing
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Womack, Julie A; Scherzer, Rebecca; Cole, Stephen R et al. (2009) Hormonal contraception and metabolic outcomes in women with or at risk for HIV infection. J Acquir Immune Defic Syndr 52:581-7
Womack, Julie (2009) HIV-related lipodystrophy in Africa and Asia. AIDS Read 19:131-9, 148-52
Womack, Julie; Richman, Susan; Tien, Phyllis C et al. (2008) Hormonal contraception and HIV-positive women: metabolic concerns and management strategies. J Midwifery Womens Health 53:362-75
Womack, Julie; Tien, Phyllis C; Feldman, Joseph et al. (2007) Obesity and immune cell counts in women. Metabolism 56:998-1004