The neural substrates of anxiety and the suppression of anxiety will be studied in humans using functional neuroimaging techniques. Positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) scans will be performed in healthy subjects who have been made anxious by behavioral manipulations such as the threat of painful electric shock. The goal of this research is to identify specific limbic and prefrontal brain regions that are involved in the generation, maintenance, and extinction of anxious emotional states. This research has implications for a variety of anxiety disorders such as panic disorder, simple phobias, and post-traumatic stress disorder.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS010196-04
Application #
2891514
Study Section
Special Emphasis Panel (ZRG4-GRM (03))
Program Officer
Heetderks, William J
Project Start
1999-08-01
Project End
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Washington University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130