The objective of this project is to determine the function of select members of the ADAM family of proteins during morphogenesis and differentiation of the neural crest. This research project will utilize chick embryos and will test the hypothesis that ADAM family members regulate certain aspects of neural crest cell morphogenesis and differentiation. The ADAM proteins contain several extracellular domains including metalloprotease, disintegrin, and cysteine-rich, and are transmembrane proteins. This project will examine the ADAM family members expressed in neural crest cells, which are a transient cell population that give rise to the peripheral nervous system, structures of the eye, and pigment cells, among other tissues. Antifunctional antibodies and antisense oligonucleotides will be applied in vivo and in vitro to inhibit ADAM protein function, to determine the importance of ADAM proteins during neural crest cell migration and differentiation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NS010743-01
Application #
2775556
Study Section
Special Emphasis Panel (ZRG1-MDCN-6 (01))
Program Officer
Leblanc, Gabrielle G
Project Start
1999-03-01
Project End
Budget Start
1999-01-01
Budget End
1999-12-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California Davis
Department
Anatomy/Cell Biology
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Hall, Ronelle J; Erickson, Carol A (2003) ADAM 10: an active metalloprotease expressed during avian epithelial morphogenesis. Dev Biol 256:146-59