The main objective of this research proposal is to enhance our understanding of the cell survival-promoting activities of, with special emphasis on the central nervous system.
The specific aims are as follows: 1) To determine if treatment of cultured cerebellar granule neurons with DNA damaging agents induces changes in the activity of NF-kB/Rel proteins. 2) To evaluate if NF-kB/Rel can modulate DNA damage-induced neuronal death. 3) To study the potential mechanisms of NF-kB/Rel- mediated neuronal protection against DNA damage-induced apoptosis. On a more general level, this proposal may aid in the understanding of programmed cell death and cellular response to DNA damage, which are directly related to cancer and chemo/radio-therapy. Furthermore, NF- kB/Rel has been demonstrated to be involved in a wide range of biological processes, including infection, inflammation, stress, proliferation, and differentiation. Exploration of the mechanisms of NF-kB/Rel activity and regulation will hopefully lead to a greater understanding of all of these processes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS011060-02
Application #
6402847
Study Section
Special Emphasis Panel (ZRG1-IFCN-5 (02))
Program Officer
Heemskerk, Jill E
Project Start
2001-07-31
Project End
Budget Start
2001-07-31
Budget End
2002-07-30
Support Year
2
Fiscal Year
2001
Total Cost
$20,138
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Pharmacology
Type
Schools of Medicine
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854