Peptide Tyrosine Tyrosine (PYY3-36) is an endogenous humoral peptide that has been shown to increase postprandially in proportion to the calorie content of meals. PYY3-36 has also been shown to inhibit food intake in animals and humans, thus, the understanding of its function is important both scientifically and clinically. The long-term goal of the proposed research is to understand the role of PYY3-36 in the intricate balance of energy homeostasis. There are several aspects of PYY3-36 action that are of interest, such as the anatomical site of its action and involvement of the melanocortin system in the generation of physiological output response to postprandial secretion of the peptide. Furthermore, we would like to compare the action PYY3-36 to PYY1-36 and also elucidate the physiological role of PYY3-36 as a peripheral feedback signal of the satiety response. Finally, we are interested in determining whether PYY3-36 is acting as a short or long-term peripheral signal to the CNS. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NS048773-01
Application #
6791662
Study Section
Special Emphasis Panel (ZRG1-F06 (20))
Program Officer
Mitler, Merrill
Project Start
2004-05-01
Project End
2007-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
1
Fiscal Year
2004
Total Cost
$31,758
Indirect Cost
Name
Oregon Health and Science University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Ellacott, Kate L J; Halatchev, Ilia G; Cone, Roger D (2006) Characterization of leptin-responsive neurons in the caudal brainstem. Endocrinology 147:3190-5
Halatchev, Ilia G; Cone, Roger D (2005) Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice. Cell Metab 1:159-68