Recent laboratory research has demonstrated sufficient nerve regeneration of the damaged spinal cord in animals to enable some recovery of motor ability. However, many unanswered questions remain both in animal experiments and in the development of human therapies. The development of computer-based simulation models can enhance investigation into the cellular basis of nerve regeneration in acute spinal cord injury. These models will represent a complex biological system in a quantitative way by using data from in vitro, animal and clinical experiments. The hypothesis is that computer-based models can accelerate lab research by pointing to the most promising experiments to reduce cell damage and improve prospects for nerve regeneration. The ultimate goal is to gain insight into improved strategies for rehabilitation and therapeutics for human injury. Experimental, imaging, and genomic data can be used in the simulations and organized in a database suitable for analysis. The models will be validated against behavior observed in the lab and used to confirm understanding of biological processes as well as to suggest new experiments. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS049691-03
Application #
7116745
Study Section
Special Emphasis Panel (ZRG1-BBBP-H (29))
Program Officer
Kleitman, Naomi
Project Start
2004-09-01
Project End
2008-09-30
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
3
Fiscal Year
2006
Total Cost
$29,602
Indirect Cost
Name
University of California San Francisco
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Sorani, Marco D; Lee, Michaela; Kim, Helen et al. (2009) Raceethnicity and outcome after traumatic brain injury at a single, diverse center. J Trauma 67:75-80
Rosenthal, Guy; Hemphill 3rd, J Claude; Sorani, Marco et al. (2008) Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Crit Care Med 36:1917-24
Sorani, Marco D; Zador, Zsolt; Hurowitz, Evan et al. (2008) Novel variants in human Aquaporin-4 reduce cellular water permeability. Hum Mol Genet 17:2379-89
Sorani, Marco D; Morabito, Diane; Rosenthal, Guy et al. (2008) Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system. J Neurotrauma 25:291-8
Sorani, Marco D; Manley, Geoffrey T (2008) Dose-response relationship of mannitol and intracranial pressure: a metaanalysis. J Neurosurg 108:80-7
Sorani, Marco D; Manley, Geoffrey T; Giacomini, Kathleen M (2008) Genetic variation in human aquaporins and effects on phenotypes of water homeostasis. Hum Mutat 29:1108-17
Sorani, Marco D; Hemphill 3rd, J Claude; Morabito, Diane et al. (2007) New approaches to physiological informatics in neurocritical care. Neurocrit Care 7:45-52