A fundamental feature of the mammalian visual system is its decomposition of the visual image into specialized streams of information, some dedicated to processing motion, others to object shape or color. Although these channels have been well-defined from their origin in the retina to several regions of the visual cortex, less is known about how they are eventually re-integrated to obtain accurate interpretations of the visual world. We are currently investigating how two different motion-processing pathways in the visual cortex of the macaque (a direct V1-MT pathway and an indirect V1-V2A/3-MT pathway), combine information to obtain accurate interpretations of how objects move. We are doing this by using a reversible-inactivation technique (localized cooling) to silence neuronal activity of areas V2 and V3 in the awake behaving macaque. By recording from neurons in the motion-processing area MT and recording ocular behavior, we will identify the specific visual deficiencies that arise when the above extrastriate areas do not contribute to the analysis of motion.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NS052926-01
Application #
6984228
Study Section
Special Emphasis Panel (ZRG1-DIG-B (29))
Program Officer
Babcock, Debra J
Project Start
2005-09-01
Project End
2008-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
1
Fiscal Year
2005
Total Cost
$35,435
Indirect Cost
Name
Harvard University
Department
Genetics
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Ponce, Carlos R; Hunter, J Nicholas; Pack, Christopher C et al. (2011) Contributions of indirect pathways to visual response properties in macaque middle temporal area MT. J Neurosci 31:3894-903
Ponce, Carlos R; Lomber, Stephen G; Born, Richard T (2008) Integrating motion and depth via parallel pathways. Nat Neurosci 11:216-23