Signaling pathways in the brain that mediate the physiological components of the response to a bacterial infection - including fever accompanied by tachycardia and activation of the hypothalamic-pituitary adrenal axis - are still unknown. To address this question, I plan to study the role of the dorsomedial hypothalamus (DMH) and the raphe pallidus (RP) in the changes caused by systemic administration of lipopolysaccharide (LPS), a model for the innate immune response in rats. I hypothesize that the DMH mediates increases in body temperature, heart rate and plasma adrenocorticotropic hormone (ACTH) induced by systemic administration of LPS in conscious rats, and that the RP specifically mediates increases in body temperature and heart rate induced by systemic administration of LPS in conscious rats via signaling from the DMH. Chemical inhibition with muscimol, a neuronal inhibitor, will be used to assess the role of the DMH and the RP in the physiological components of the response to LPS, and anatomic correlates will be examined using combined retrograde tracing and fos immunocytochemistry.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NS052929-01
Application #
6986853
Study Section
Special Emphasis Panel (ZRG1-DIG-B (29))
Program Officer
Mitler, Merrill
Project Start
2005-12-01
Project End
2008-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
1
Fiscal Year
2005
Total Cost
$35,899
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Pharmacology
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202