In the broadest sense, we are interested in determining whether clock genes (Perl, Per2, Bmal, and Clk) are involved in hippocampal physiology and whether they impose a temporal structure to learning and memory functions. In order to test this general hypothesis, we propose to address a series of approachable questions: 1) Are clock genes rhythmically expressed in the HIP? 2) Are these rhythms restricted to certain cell populations within the HIP? 3) Does the induction of long term potentiation regulate the expression of these genes and does this regulation vary with a daily cycle? 4) Does membrane depolarization and calcium influx drive mPER expression in the HIP? We provide preliminary data indicating that our experimental hypotheses are likely to be confirmed. In addressing these questions, we hope to better understand the possible role of clock genes in synaptic plasticity as well as provide insights as to how the circadian system imposes a temporal structure to learned behaviors ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NS054366-01
Application #
7053589
Study Section
Special Emphasis Panel (ZRG1-F02A (20))
Program Officer
Mitler, Merrill
Project Start
2006-04-01
Project End
2008-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
1
Fiscal Year
2006
Total Cost
$29,418
Indirect Cost
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095