Thalamic activity, and ultimately cortical processing, is strongly affected by fluctuating subthreshold membrane potential levels in the thalamus, or the thalamic state. It has long been posited that hyperpolarizing the thalamus will lead to a 'burst'firing mode while depolarizing the thalamus will lead to a 'tonic'firing mode. Although we have some knowledge of the firing modes induced by thalamic state, we do not have a clear understanding of how these firing modes affect the transmission of sensory information. Previous work in our lab has suggested that the 'burst'mode may be indicative of a 'detect'mode while a 'tonic'mode may be better suited for a 'discrimination'mode. In this work, I plan to comprehensively examine the role of imposed thalamic states on the encoding of somatosensory information in the rat whisker pathway. By manipulating thalamic state using optogenetic methodologies, I will be able to explicitly test hypotheses about the relationship between firing mode and information transmission in anesthetized and awake behaving animals. The results of this work could have multiple clinical applications. The thalamus is a critical structure implicated in both sensory and motor function. An understanding of how to manipulate the state of the thalamus to achieve a desired level of information transmission could lead to improved sensory prosthetics, alternative thalamic pain relief methodologies, or restorative motor control. The role thalamic state on information flow could be extended to other brain regions, permitting alternative methods of controlling information flow in clinical applications such as deep brain stimulation. A more complete understand of how the constantly fluctuating state of the thalamus, and the brain, is affecting the transmission of information is critical for he clinical success of engineered applications.

Public Health Relevance

The objective of this study is to understand how the state of the thalamus affects the transmission of sensory information. A more complete understanding of how the dynamic encoding of sensory information is modulated by thalamic state would provide a mechanism to control information flow in the central nervous system. This could have multiple clinical applications including improved sensory prosthetics, alternative deep brain stimulation methodologies, thalamic pain relief, or restorative motor control.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Predoctoral Individual National Research Service Award (F31)
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Special Emphasis Panel (ZRG1)
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Gnadt, James W
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Georgia Institute of Technology
Engineering (All Types)
Biomed Engr/Col Engr/Engr Sta
United States
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