Moderate alcohol intake is thought to be cardioprotective. The postulated mechanism has always been the elevated high-density lipoprotein cholesterol concentration seen in alcohol consumers compared to nondrinkers. Recent studies have raised the possibility that insulin sensitivity may be mediating the effect between moderate alcohol consumption and lowered cardiovascular disease (CVD) risk. This study therefore has the following aims: 1.To assess whether the daily consumption of a moderate amount of alcohol can improve insulin sensitivity in a volunteer group of nondrinkers predefined as insulin resistant. 2. To determine if moderate alcohol intake by improving insulin sensitivity will have the beneficial metabolic outcomes in HDL, insulin and glucose to lower CVD risk. 3. To investigate if measures of endothelial function (asymmetric dimethylarginine and soluble cellular adhesion molecules) as risk factors for CVD are affected by moderate alcohol consumption and insulin sensitivity. Insulin sensitivity/resistance will be measured by the insulin suppression test. Given the morbidity and mortality of insulin resistance and CVD, it becomes important to clarify the role of moderate alcohol consumption to both.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AA014470-03
Application #
6985413
Study Section
Special Emphasis Panel (ZAA1-GG (11))
Program Officer
Brown, Ricardo A
Project Start
2003-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
3
Fiscal Year
2006
Total Cost
$70,396
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305