The objective of this independent postdoctoral fellowship award (F32) is to support the candidate's training goals to gain knowledge on substance use and psychiatric outcomes, expertise in genetic epidemiological and gene-finding methods, and further develop the skills needed for an academic research career. To achieve these training goals, the candidate will use genetically informed designs to characterize the associations between externalizing behavior and relationship factors. Numerous studies document associations among externalizing behavior (e.g., alcohol and illicit drug abuse and dependence and antisocial behavior), marital status, and romantic relationship dysfunction. Externalizing behavior and relationship traits are both under genetic influence;still, little is known about their associations from a genetic perspective. Characterizing these associations is important in view of growing evidence that genetic predispositions and environmental risk factors are not independent of one another. With respect to the present project, for example, behavioral disinhibition (i.e., the highly heritable factor shared among externalizing behaviors) also compromises the interpersonal processes (e.g., conflict resolution, trust, and commitment) that are central to the formation and maintenance of harmonious romantic relationships. Two central hypotheses guide this work. First, it is expected that marital status and relationship dysfunction will have a common genetic basis with externalizing behavior. Second, it is expected that, after accounting for gene-environment correlation, marital status and relationship dysfunction will moderate genetic influences on externalizing behavior. The first part of this project will use genetic epidemiological (i.e., twin) methods to examine whether externalizing behavior and romantic relationship factors share latent genetic influences and whether romantic relationship factors moderate latent genetic influences on externalizing behavior. The second part of this project will use gene-finding methods to examine whether externalizing behavior and relationship factors share measured genetic influences, and whether relationship factors moderate measured genetic influences on externalizing behavior. Thus, this work uses complementary genetically-informed methods (twin studies and gene identification methods) to determine the extent to which genetic and/or environmental influences toward externalizing behavior also influence one's propensity to marry, divorce, or have a dysfunctional relationship, and whether relationship factors moderate genetic influences on externalizing behavior. This work contributes to a central goal of psychiatric research, which is to understand how salient environmental factors, such as marital status and relationship dysfunction, come together with genetic predispositions to predict the onset and course of disorders.

Public Health Relevance

The proposed research is relevant to public health because it considers how relationship-related environmental factors in adulthood come together with genetic predispositions to predict socially costly externalizing behaviors (e.g., alcohol and illict drug abuse and dependence and antisocial behavior). The project is relevant to NIH's mission because it aims to provide basic scientific insights into gene- environment correlation and gene-environment interaction processes underlying this important public health problem. The findings may have implications for preventive intervention efforts that focus on bolstering relationship skills as a way to protect individuals at genetic risk for externalizing behavior from close relationship experiences that would worsen their predispositions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32AA022269-01A1
Application #
8641885
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Parsian, Abbas
Project Start
2013-09-05
Project End
2015-09-04
Budget Start
2013-09-05
Budget End
2014-09-04
Support Year
1
Fiscal Year
2013
Total Cost
$54,890
Indirect Cost
Name
Virginia Commonwealth University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Aliev, Fazil; Salvatore, Jessica E; Agrawal, Arpana et al. (2018) A Brief Critique of the TATES Procedure. Behav Genet 48:155-167
Docherty, Anna R; Moscati, Arden; Dick, Danielle et al. (2018) Polygenic prediction of the phenome, across ancestry, in emerging adulthood. Psychol Med 48:1814-1823
Salvatore, Jessica E; Dick, Danielle M (2018) Genetic influences on conduct disorder. Neurosci Biobehav Rev 91:91-101
Bucholz, Kathleen K; McCutcheon, Vivia V; Agrawal, Arpana et al. (2017) Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. Alcohol Clin Exp Res 41:359-368
Li, James J; Cho, Seung Bin; Salvatore, Jessica E et al. (2017) The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood. Alcohol Clin Exp Res 41:65-75
Barr, Peter B; Salvatore, Jessica E; Maes, Hermine H et al. (2017) Social Relationships Moderate Genetic Influences on Heavy Drinking in Young Adulthood. J Stud Alcohol Drugs 78:817-826
Salvatore, Jessica E; Cho, Seung Bin; Dick, Danielle M (2017) Genes, Environments, and Sex Differences in Alcohol Research. J Stud Alcohol Drugs 78:494-501
Haydon, Katherine C; Jonestrask, Cassandra; Guhn-Knight, Haley et al. (2017) The Dyadic Construction of Romantic Conflict Recovery Sabotage. J Soc Pers Relat 34:915-935
Goyal, Neeru; Aliev, Fazil; Latendresse, Shawn J et al. (2016) Genes involved in stress response and alcohol use among high-risk African American youth. Subst Abus 37:450-458
Barr, Peter B; Salvatore, Jessica E; Maes, Hermine et al. (2016) Education and alcohol use: A study of gene-environment interaction in young adulthood. Soc Sci Med 162:158-67

Showing the most recent 10 out of 27 publications