The broad long-term objective of the proposed research is to better understand mechanisms controlling skeletal muscle hypertrophy in elderly men. This is relevant to elderly men as sarcopenia or the age related loss of skeletal muscle mass is highly prevalent in this population. Specifically we will be examining the effects of altered circulating testosterone concentrations, resistance training, and the combination of these two interventions on skeletal muscle hypertrophy and putatative mediators of skeletal muscle hypertrophy: insulin like growth factor I mRNA, insulin like growth factor I protein, and satellite cell activation (skeletal muscle concentrations of MyoD and myogenin). We will alter testosterone concentrations with megestrol acetate and testosterone administration and will induce skeletal muscle hypertrophy with resistance training in the following experimental design: 1) A non-intervention control group; 2) megestrol acetate administration; 3) megestrol acetate administration + resistance training; 4) megestrol acetate administration + 100 mg of testosterone enanthate per week; 5) megestrol acetate administration + resistance training + 100 mg of testosterone enanthate per week.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AG005873-03
Application #
6475584
Study Section
Geriatrics and Rehabilitation Medicine (GRM)
Program Officer
Rossi, Winifred K
Project Start
2001-12-15
Project End
Budget Start
2001-12-15
Budget End
2002-11-30
Support Year
3
Fiscal Year
2002
Total Cost
$43,772
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Other Health Professions
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Lambert, Charles P; Flynn, Michael G; Sullivan, Dennis H et al. (2004) Effects of megestrol acetate on circulating interleukin-15 and interleukin-18 concentrations in healthy elderly men. J Gerontol A Biol Sci Med Sci 59:855-8
Lambert, Charles P; Sullivan, Dennis H; Evans, William J (2003) Effects of testosterone replacement and/or resistance training on interleukin-6, tumor necrosis factor alpha, and leptin in elderly men ingesting megestrol acetate: a randomized controlled trial. J Gerontol A Biol Sci Med Sci 58:165-70
Lambert, Charles P; Archer, R Lee; Carrithers, John A et al. (2003) Influence of creatine monohydrate ingestion on muscle metabolites and intense exercise capacity in individuals with multiple sclerosis. Arch Phys Med Rehabil 84:1206-10
Lambert, Charles P; Sullivan, Dennis H; Evans, William J (2003) Megestrol acetate-induced weight gain does not negatively affect blood lipids in elderly men: effects of resistance training and testosterone replacement. J Gerontol A Biol Sci Med Sci 58:644-7
Lambert, Charles P; Flynn, Michael G (2002) Fatigue during high-intensity intermittent exercise: application to bodybuilding. Sports Med 32:511-22
Lambert, Charles P; Sullivan, Dennis H; Freeling, Scott A et al. (2002) Effects of testosterone replacement and/or resistance exercise on the composition of megestrol acetate stimulated weight gain in elderly men: a randomized controlled trial. J Clin Endocrinol Metab 87:2100-6
Lambert, C P; Archer, R L; Evans, W J (2001) Muscle strength and fatigue during isokinetic exercise in individuals with multiple sclerosis. Med Sci Sports Exerc 33:1613-9