The long-term goal of the proposed research is to develop mechanistically well-characterized inhibitors of Beta-amyloid aggregation and Alzheimer?s disease. The specific goal of this project is to apply the concept of divalent mistemplation to the design and synthesis of a library of molecules made up of peptides attached to spatially diverse scaffolds. These molecules will be screened to determine key elements needed for various anti-amyloid activities. Conclusions will then be established about structure-activity relationships for the inhibitors and that information will be applied to the next generation of compounds.
| Derda, Ratmir; Musah, Samira; Orner, Brendan P et al. (2010) High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells. J Am Chem Soc 132:1289-95 |
| Derda, Ratmir; Li, Lingyin; Orner, Brendan P et al. (2007) Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chem Biol 2:347-55 |
| Orner, Brendan P; Liu, Lin; Murphy, Regina M et al. (2006) Phage display affords peptides that modulate beta-amyloid aggregation. J Am Chem Soc 128:11882-9 |
| Orner, Brendan P; Derda, Ratmir; Lewis, Rachel L et al. (2004) Arrays for the combinatorial exploration of cell adhesion. J Am Chem Soc 126:10808-9 |
