Abstract

The Alzheimer's Disease Patient Registry (ADPR), consisting of 300 case and 450 control subjects residing in Olmstead County, Minnesota collected by Mayo Clinic physicians is potentially a rich resource for genome-wide linkage disequilibrium (LD) mapping of genes involved in Alzheimer's Disease (AD). Because of the demographic characteristics of the county (this population is mostly made up of individuals of Scandinavian descent), this population is rather homogeneous and therefore ideal for using LD methods to identify risk variants. We plan on using both pair-wise and multipoint LD methods to define the risk allele(s) within the previously identified late-onset AD candidate gene-containing loci (focusing on the Chromosome 9p22.1 locus first). To reduce the risk of false positive results from the analysis, examination of ADPR population homogeneity at a genetic level will be performed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AG024030-03
Application #
7126023
Study Section
Special Emphasis Panel (ZRG1-F01 (20))
Program Officer
Miller, Marilyn
Project Start
2004-10-01
Project End
2007-09-30
Budget Start
2006-10-01
Budget End
2007-09-30
Support Year
3
Fiscal Year
2006
Total Cost
$53,488
Indirect Cost

  Institution

Name
Mayo Clinic Jacksonville
Department
Type
DUNS #
153223151
City
Jacksonville
State
FL
Country
United States
Zip Code
32224

  Publications

Sando, Sigrid Botne; Melquist, Stacey; Cannon, Ashley et al. (2008) Risk-reducing effect of education in Alzheimer's disease. Int J Geriatr Psychiatry 23:1156-62
Sando, Sigrid B; Melquist, Stacey; Cannon, Ashley et al. (2008) APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease;a case control study from central Norway. BMC Neurol 8:9
Golan, Maciej P; Melquist, Stacey; Safranow, Krzysztof et al. (2008) Analysis of UBQLN1 variants in a Polish Alzheimer's disease patient: control series. Dement Geriatr Cogn Disord 25:366-71
Gass, Jennifer; Cannon, Ashley; Mackenzie, Ian R et al. (2006) Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. Hum Mol Genet 15:2988-3001
Mackenzie, Ian R; Baker, Matthew; West, Gemma et al. (2006) A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17. Brain 129:853-67
Rademakers, Rosa; Melquist, Stacey; Cruts, Marc et al. (2005) High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy. Hum Mol Genet 14:3281-92
Toft, Mathias; Sando, Sigrid Botne; Melquist, Stacey et al. (2005) LRRK2 mutations are not common in Alzheimer's disease. Mech Ageing Dev 126:1201-5