Abstract

Heart failure is one of the most significant causes of hospitalization, morbidity and mortality among elderly individuals in the United States. Research has demonstrated that patients with heart failure show cognitive impairment, which can impact functional abilities and quality of life. Medical interventions including implanted devices have led to improvements in symptom control and slowed progression of disease among patients with heart failure. Cardiac resynchronization therapy (CRT), a recently developed pacemaker based intervention, is associated with improvements on a range of cardiac functioning measures as well as enhanced health status and quality of life. However, no studies have examined cognitive functioning in this population, particularly in the context of change in cardiac functioning before and after CRT. In the present study, cardiac function and cognition will be examined among patients with heart failure before and after cardiac resynchronization therapy. This integration of cardiac and cognitive measures will help to elucidate the mechanisms by which cardiac disease is associated with cognitive decline, and will provide data on the effects of CRT on cognition.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AG026850-02
Application #
7118254
Study Section
Special Emphasis Panel (ZRG1-RPHB-A (21))
Program Officer
Wagster, Molly V
Project Start
2005-09-01
Project End
2007-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
2
Fiscal Year
2006
Total Cost
$44,476
Indirect Cost

  Institution

Name
Miriam Hospital
Department
Type
DUNS #
063902704
City
Providence
State
RI
Country
United States
Zip Code
02906

  Publications

Hoth, Karin F; Poppas, Athena; Ellison, Kristin E et al. (2010) Link between change in cognition and left ventricular function following cardiac resynchronization therapy. J Cardiopulm Rehabil Prev 30:401-8
Jerskey, Beth A; Cohen, Ronald A; Jefferson, Angela L et al. (2009) Sustained attention is associated with left ventricular ejection fraction in older adults with heart disease. J Int Neuropsychol Soc 15:137-41
Cohen, Ronald A; Poppas, Athena; Forman, Daniel E et al. (2009) Vascular and cognitive functions associated with cardiovascular disease in the elderly. J Clin Exp Neuropsychol 31:96-110
Gunstad, John; Keary, Therese Anne; Spitznagel, Mary Beth et al. (2009) Blood pressure and cognitive function in older adults with cardiovascular disease. Int J Neurosci 119:2228-42
Haley, Andreana P; Hoth, Karin F; Gunstad, John et al. (2009) Subjective cognitive complaints relate to white matter hyperintensities and future cognitive decline in patients with cardiovascular disease. Am J Geriatr Psychiatry 17:976-85
Stanek, Kelly M; Gunstad, John; Paul, Robert H et al. (2009) Longitudinal cognitive performance in older adults with cardiovascular disease: evidence for improvement in heart failure. J Cardiovasc Nurs 24:192-7
Hoth, Karin F; Poppas, Athena; Moser, David J et al. (2008) Cardiac dysfunction and cognition in older adults with heart failure. Cogn Behav Neurol 21:65-72
Hoth, Karin F; Haley, Andreana P; Gunstad, John et al. (2008) Elevated C-reactive protein is related to cognitive decline in older adults with cardiovascular disease. J Am Geriatr Soc 56:1898-903
Hoth, Karin F; Nash, Justin; Poppas, Athena et al. (2008) Effects of cardiac resynchronization therapy on health-related quality of life in older adults with heart failure. Clin Interv Aging 3:553-60
Hoth, Karin F; Tate, David F; Poppas, Athena et al. (2007) Endothelial function and white matter hyperintensities in older adults with cardiovascular disease. Stroke 38:308-12

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