Sleep has been demonstrated to promote the reactivation (""""""""replay"""""""") and consolidation of important memories and the pruning of irrelevant memories. Consolidation and pruning typically occur during slow wave sleep (i.e., deep sleep), in which memories are transferred from temporary storage in hippocampal regions to long-term storage in neocortical regions. Thus, sleep is vital to daytime cognitive functioning. Nearly all sleep-dependent memory consolidation and pruning research has examined sleep and memory in college-aged adults, thereby ignoring how memory consolidation and pruning may change with normal aging and in clinical sleep disorders. This omission may be particularly crucial because substantial sleep physiology changes (including slow wave sleep declines) and profound memory declines have been reported in healthy older adults and those with mild cognitive impairment and sleep-disordered breathing. The current proposal focuses on this intriguing sleep-memory-aging relationship to determine how age-related sleep changes impact age-related memory changes. Younger adults, healthy older adults, and adults who have mild cognitive impairment as well as sleep-disordered breathing, will encode memories that they are either told will be important in the future or irrelevant in the future, and then they will take a polysomnography-recorded nap. Following the nap, they will be tested on their ability to remember """"""""important"""""""" memories and forget """"""""irrelevant"""""""" memories. Memory performance will be correlated with polysomnography-defined sleep features such as amount of slow wave sleep. The results will shed light on whether sleep-dependent memory consolidation and pruning processes are impaired in healthy older adults and those with clinical sleep disorders. The results will also provide information regarding how the sleep-memory relationship may change from younger adults to older adults;such knowledge can subsequently be used to develop cognitive rehabilitation treatments for healthy older adults, mild cognitive impairment patients, and sleep-disordered breathing patients. For example, if slow wave sleep changes mediate group deficits in memory then a potentially effective treatment might entail prescribing slow wave sleep enhancers. Or, if sleep-disordered breathing events cause memory consolidation/pruning declines then continuous positive airway pressure (CPAP) treatment might be appropriate. Finally, if memory consolidation and/or pruning are relatively preserved during sleep in older adults then a useful intervention may include strategically timed naps during the day. This research will advance knowledge of cognitive aging beyond the waking brain to the exciting new frontier of the sleeping brain.

Public Health Relevance

Deep sleep is critical to memory functioning in college-aged adults. Older adults, however, often show dramatic changes in their sleep physiology, implying that they may not receive the full memory benefits of sleeping. The proposed research will investigate how sleep and memory changes in normal aging and in sleep-disordered breathing patients so that we may eventually develop effective sleep-based interventions to help ameliorate memory declines in these populations.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Postdoctoral Individual National Research Service Award (F32)
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Special Emphasis Panel (ZRG1-F02B-M (20))
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Mackiewicz, Miroslaw
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Emory University
Schools of Medicine
United States
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Scullin, Michael K; Fairley, Jacqueline; Decker, Michael J et al. (2017) The Effects of an Afternoon Nap on Episodic Memory in Young and Older Adults. Sleep 40:
Bliwise, Donald L; Greer, Sophia A; Scullin, Michael K et al. (2017) Habitual and Recent Sleep Durations: Graded and Interactive Risk for Impaired Glycemic Control in a Biracial Population. Am J Med 130:564-571
Factor, Stewart A; Scullin, Michael K; Freeman, Alan et al. (2017) Affective Correlates of Psychosis in Parkinson's Disease. Mov Disord Clin Pract 4:225-230
Scullin, Michael K; Bliwise, Donald L (2015) Sleep, cognition, and normal aging: integrating a half century of multidisciplinary research. Perspect Psychol Sci 10:97-137
Scullin, Michael K; Fairley, Jacqueline A; Trotti, Lynn Marie et al. (2015) Sleep correlates of trait executive function and memory in Parkinson's disease. J Parkinsons Dis 5:49-54
Factor, S A; Scullin, M K; Sollinger, A B et al. (2014) Freezing of gait subtypes have different cognitive correlates in Parkinson's disease. Parkinsonism Relat Disord 20:1359-64
Factor, Stewart A; Scullin, Michael K; Sollinger, Ann B et al. (2014) Cognitive correlates of hallucinations and delusions in Parkinson's disease. J Neurol Sci 347:316-21
Scullin, Michael K; Harrison, Tyler L; Factor, Stewart A et al. (2014) A Neurodegenerative Disease Sleep Questionnaire: principal component analysis in Parkinson's disease. J Neurol Sci 336:243-6
Bugg, Julie M; Scullin, Michael K; McDaniel, Mark A (2013) Strengthening encoding via implementation intention formation increases prospective memory commission errors. Psychon Bull Rev 20:522-7
Scullin, Michael K; Bugg, Julie M (2013) Failing to forget: prospective memory commission errors can result from spontaneous retrieval and impaired executive control. J Exp Psychol Learn Mem Cogn 39:965-71

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