The first part of this proposal is aimed at testing if Ail, a small outer membrane protein and a potential adhesion from human pathogen Yersinia enterocolitica, interacts directly with the mammalian cells to promote bacterial attachment and invasion. Under the presupposition that such direct interactions are real, as suggested by previous evidence, the second part of the proposal is designed to identify the receptor(s) for Ail. The long term goal of this project is to understand the signal transduction events triggered by the interactions between Ail and its receptor(s) that result in the internalization of the bacteria.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
7F32AI009268-03
Application #
2751216
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1997-04-01
Project End
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Dentistry
Type
Schools of Dentistry
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260