We plan to look at latency in acute HIV infection. Using flow cytometry, we plan to purify different cell populations from whole blood and lymphnodes of patients with acute HIV infection. We will determine what percentage of different cell populations are infected and we will monitor how this changes with time. Using PCR, we will determine how soon latency is established in the course of acute infection. We will also determine how much of the drop in viremia after seroconversion is due to trapping of virions as immune complexes versus the elimination of a subpopulation of infected cells. We will also determine whether latency can be prevented by the early initiation of highly antiretroviral therapy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AI010140-02
Application #
6141677
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Sager, Polly R
Project Start
1998-07-01
Project End
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218