Broad long-term goals of the proposed project are 1) to develop the first hierarchical dynamic model of human malaria, 2) to calibrate this model further through work with laboratory-based colleagues on parallel systems, and with field-based and clinic-based colleagues on analyses of longitudinal studies, and 3) to use the resulting model to aid in predicting and evaluating effects of proposed interventions in malaria dynamics.
Specific aims are 1) during the first 18 months, to develop major extensions of models within the general scheme of separate individual-level and population-level models, and, 2) during the last 18 months, to meet two further challenges: developing a new form of individual-level model that encompasses diverse phenomena on multiple time scales, and deciding on the best method for nesting individual- level models within fully integrated population-level models, to produce a hierarchical dynamic model capable of addressing the wide range of interacting individual-level and population-level phenomena in human malaria. Each of the specific tasks targets a critical but poorly- understood aspect of parasitological and immunological dynamics in individual-level, clinically-related phenomena or of parasitological, immunological and transmission dynamics in population-level, epidemiologically-related phenomena.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AI010174-02
Application #
2886324
Study Section
Special Emphasis Panel (ZRG5-TMP (01))
Program Officer
Fairfield, Alexandra
Project Start
1999-07-01
Project End
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Harvard University
Department
Engineering (All Types)
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138