Ras signaling is important in many different cellular fate choices that occur during development, including alphabeta T cell maturation. Mice expressing a transgene encoding a dominant- negative form of Ras exhibit a reduction in the number of mature alphabeta T cells. As Ras has several effector pathways, these studies do not indicate which downstream cascades are involved in T cell maturation. One of these pathways, the ERK/MAPK cascade, has been shown to be necessary, but not sufficient for this process. It is the goal of this proposal to identify and characterize other signaling pathways required for Ras-mediated aplphabeta T cell maturation by analyzing the effects of various Ras effector mutants in an ex vivo model of T cell development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AI010466-02
Application #
6372920
Study Section
Special Emphasis Panel (ZRG1-IMB (01))
Program Officer
Prograis, Lawrence J
Project Start
2001-07-01
Project End
Budget Start
2001-07-01
Budget End
2001-12-31
Support Year
2
Fiscal Year
2001
Total Cost
$22,598
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125