The cause of rheumatoid arthritis (RA) is currently unclear, but it has been speculated that the accumulation of fluid and subsequent damage to joints is the result of an autoimmune response. Activation of the cAMP dependent pathway has been shown to inhibit immune responses, and evidence also exists supporting a role for protein phosphorylation in this inhibition. The subcellular targeting and localization of protein kinases and phosphatases has emerged as an essential mechanism in the regulation of phosphorylation events. Therefore it is a goal of this proposal to study the role of subcellular targeting of the cAMP dependent protein kinase (PKA) in regulating immune response. The proposed studies will use methods and reagents currently used in Dr. Carr's laboratory and will specifically address 1) the importance of anchored PKA activity in mediating an immune response, and 2) the identification of PKA anchoring proteins in T lymphocytes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AI010520-02
Application #
6372929
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
Prograis, Lawrence J
Project Start
2001-07-01
Project End
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
2
Fiscal Year
2001
Total Cost
$43,772
Indirect Cost
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239