Abstract

The purpose of this proposal is to develop rhesus cytomegalovirus (RhCMV) as model system for studying human cytomegalovirus pathogenesis. Specifically, we will be studying the growth determinants of RhCMV in monocyte-derived macrophages (also infected by human immunodeficiency virus or simian immunodeficiency virus), by using a transposon mutagenesis system and bacterial artificial chromosome (BAC) technology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32AI057218-01
Application #
6694843
Study Section
AIDS and Related Research 8 (AARR)
Program Officer
Lambros, Chris
Project Start
2003-09-01
Project End
2005-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
1
Fiscal Year
2003
Total Cost
$46,420
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Rue, Cary A; Jarvis, Michael A; Knoche, Amber J et al. (2004) A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism. J Virol 78:12529-36