Abstract

Th2 cytokine responses are required for immunity to helminth parasites and are also responsible for the detrimental inflammation associated with allergies and asthma. Given the global prevalence of soil transmitted helminth infections, currently estimated at two billion individuals worldwide, coupled with the pandemic of allergic diseases in industrialized countries, it is critical to gain a better understanding of the pathways that control Th2 cytokine-mediated immunity and inflammation. Despite significant developments in our understanding of the pathways that control the differentiation and regulation of Th2 immunity, the innate immune cells that recognize helminth- or allergen-derived antigens and present them to naive CD4+ T cells remain poorly defined.
The aims of this proposal are directed at better understand those cells and mechanisms.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AI085828-02
Application #
8056629
Study Section
Special Emphasis Panel (ZRG1-F07-K (20))
Program Officer
Wali, Tonu M
Project Start
2010-03-05
Project End
2013-03-04
Budget Start
2011-03-05
Budget End
2012-03-04
Support Year
2
Fiscal Year
2011
Total Cost
$51,326
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Rak, Gregory D; Osborne, Lisa C; Siracusa, Mark C et al. (2016) IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing. J Invest Dermatol 136:487-496
Kim, Brian S; Wang, Kelvin; Siracusa, Mark C et al. (2014) Basophils promote innate lymphoid cell responses in inflamed skin. J Immunol 193:3717-25
Hill, D A; Siracusa, M C; Ruymann, K R et al. (2014) Omalizumab therapy is associated with reduced circulating basophil populations in asthmatic children. Allergy 69:674-7
Noti, Mario; Kim, Brian S; Siracusa, Mark C et al. (2014) Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis. J Allergy Clin Immunol 133:1390-9, 1399.e1-6
Osborne, Lisa C; Monticelli, Laurel A; Nice, Timothy J et al. (2014) Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation. Science 345:578-82
Siracusa, Mark C; Saenz, Steven A; Wojno, Elia D Tait et al. (2013) Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity 39:1158-70
Noti, Mario; Wojno, Elia D Tait; Kim, Brian S et al. (2013) Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat Med 19:1005-13
Kim, Brian S; Siracusa, Mark C; Saenz, Steven A et al. (2013) TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci Transl Med 5:170ra16
Siracusa, Mark C; Kim, Brian S; Spergel, Jonathan M et al. (2013) Basophils and allergic inflammation. J Allergy Clin Immunol 132:789-801; quiz 788
Saenz, Steven A; Siracusa, Mark C; Monticelli, Laurel A et al. (2013) IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. J Exp Med 210:1823-37

Showing the most recent 10 out of 14 publications