Abstract

The newest generation of micro computed tomography (microCT) scanners, incorporating improved beam- hardening corrections, have the potential to provide simultaneous assessment of both micro-architecture and tissue mineralization. A second emerging modality for bone composition analysis is Fourier transform infrared microspectroscopic imaging (FTIRI), which provides complementary spatial measures of mineralization and mineral quality. The objective of this proposal is to develop a method for the simultaneous assessment of trabecular bone structure and composition incorporating microCT-based 3D mineralization data and FTIRI-derived 2D compositional information, and to utilize this method to investigate the effects of osteoporosis progression in human subjects. Relationships among mineralization measures and morphological features will be investigated. Once established, this technique will provide a powerful tool in bone quality studies, for example in quantifying changes in mineralization associated with age, disease, or drug treatment, determining spatial mineralization patterns associated with bone turn-over mechanisms, or exploring relationships between mineral quality, tissue damage, & bone strength. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32AR053446-01
Application #
7057698
Study Section
Special Emphasis Panel (ZRG1-SBIB-H (20))
Program Officer
Lester, Gayle E
Project Start
2006-03-01
Project End
2008-02-28
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
1
Fiscal Year
2006
Total Cost
$45,976
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Kaynia, Narges; Soohoo, Elaine; Keaveny, Tony M et al. (2015) Effect of intraspecimen spatial variation in tissue mineral density on the apparent stiffness of trabecular bone. J Biomech Eng 137:
Wang, Ji; Kazakia, Galateia J; Zhou, Bin et al. (2015) Distinct Tissue Mineral Density in Plate- and Rod-like Trabeculae of Human Trabecular Bone. J Bone Miner Res 30:1641-50
Carriero, A; Zimmermann, E A; Paluszny, A et al. (2014) How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone. J Bone Miner Res 29:1392-1401
Kazakia, G J; Speer, D; Shanbhag, S et al. (2011) Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor. Calcif Tissue Int 89:10-20
Sekhon, Kiranjit; Kazakia, Galateia J; Burghardt, Andrew J et al. (2009) Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography. Bone 45:473-9
Burghardt, A J; Kazakia, G J; Link, T M et al. (2009) Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography. Osteoporos Int 20:2017-24
Burghardt, Andrew J; Kazakia, Galateia J; Laib, Andres et al. (2008) Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography. Calcif Tissue Int 83:129-38
Kazakia, G J; Burghardt, A J; Cheung, S et al. (2008) Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements. Med Phys 35:3170-9