Abstract

Investigate the anti-inflammatory (protease and immunoregulatory) effects of Bromelain, a commonly used nutritional supplement, in a mouse model of allergic airway disease. 1. Determine if Bromelain treatment alters lung function and/or pathophysiology in normal naive mice and in mice with OVA-induced allergic airway disease. 2. Investigate the mechanism(s) by which Bromelain treatment affects lung function and/or pathophysiology in normal mice and in mice OVA-induced allergic airway disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AT001569-03
Application #
7022281
Study Section
Special Emphasis Panel (ZAT1-CP (08))
Program Officer
Hopp, Craig
Project Start
2004-02-23
Project End
2007-02-22
Budget Start
2006-02-23
Budget End
2007-02-22
Support Year
3
Fiscal Year
2006
Total Cost
$62,336
Indirect Cost

  Institution

Name
University of Connecticut
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Secor Jr, Eric R; Singh, Anurag; Guernsey, Linda A et al. (2009) Bromelain treatment reduces CD25 expression on activated CD4+ T cells in vitro. Int Immunopharmacol 9:340-6
Singh, Anurag; Carson 4th, William F; Secor Jr, Eric R et al. (2008) Regulatory role of B cells in a murine model of allergic airway disease. J Immunol 180:7318-26
Juhasz, Bela; Thirunavukkarasu, Mahesh; Pant, Rima et al. (2008) Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium. Am J Physiol Heart Circ Physiol 294:H1365-70
Kabbur, Prakash M; Carson 4th, William F; Guernsey, Linda et al. (2006) Interleukin-10 does not mediate inhalational tolerance in a chronic model of ovalbumin-induced allergic airway disease. Cell Immunol 239:67-74
Schramm, C M; Guernsey, L; Secor, E et al. (2006) Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin. Biochim Biophys Acta 1762:499-501
Secor Jr, Eric R; Carson 4th, William F; Cloutier, Michelle M et al. (2005) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cell Immunol 237:68-75