Investigate the anti-inflammatory (protease and immunoregulatory) effects of Bromelain, a commonly used nutritional supplement, in a mouse model of allergic airway disease. 1. Determine if Bromelain treatment alters lung function and/or pathophysiology in normal naive mice and in mice with OVA-induced allergic airway disease. 2. Investigate the mechanism(s) by which Bromelain treatment affects lung function and/or pathophysiology in normal mice and in mice OVA-induced allergic airway disease.
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|Juhasz, Bela; Thirunavukkarasu, Mahesh; Pant, Rima et al. (2008) Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium. Am J Physiol Heart Circ Physiol 294:H1365-70|
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|Schramm, C M; Guernsey, L; Secor, E et al. (2006) Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin. Biochim Biophys Acta 1762:499-501|
|Secor Jr, Eric R; Carson 4th, William F; Cloutier, Michelle M et al. (2005) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cell Immunol 237:68-75|