Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32CA073031-02
Application #
2458297
Study Section
Biological Sciences 2 (BIOL)
Project Start
1997-08-01
Project End
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Uemura, Y; Pak, S C; Luke, C et al. (2000) Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. Int J Cancer 89:368-77
Luke, C; Schick, C; Tsu, C et al. (2000) Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage. Biochemistry 39:7081-91
Cataltepe, S; Gornstein, E R; Schick, C et al. (2000) Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. J Histochem Cytochem 48:113-22
Cataltepe, S; Schick, C; Luke, C J et al. (2000) Development of specific monoclonal antibodies and a sensitive discriminatory immunoassay for the circulating tumor markers SCCA1 and SCCA2. Clin Chim Acta 295:107-27
Schick, C; Pemberton, P A; Shi, G P et al. (1998) Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Biochemistry 37:5258-66
Bartuski, A J; Kamachi, Y; Schick, C et al. (1998) A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. Genomics 54:297-306
Silverman, G A; Bartuski, A J; Cataltepe, S et al. (1998) SCCA1 and SCCA2 are proteinase inhibitors that map to the serpin cluster at 18q21.3. Tumour Biol 19:480-7
Schick, C; Bromme, D; Bartuski, A J et al. (1998) The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition. Proc Natl Acad Sci U S A 95:13465-70
Bartuski, A J; Kamachi, Y; Schick, C et al. (1997) Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. Genomics 43:321-8