Scientific Merit; The goal of the proposed studies is to elucidate the signalling mechanisms involved in the activation of the transcription factor NF-kB. NF-kB is an inducible factor that is held in an inactive state i the cytoplasm by the inhibitory protein IkB. Exposure of cells to appropriate stimuli results in rapid phosphorylation and subsequent degradation of IkB with a resulting translocation of NF-kB to the nucleus, where it is involved in activation of gene transcription. The candidate proposes to identify the protein kinase that is responsible for phosphorylating IkB and then to study the mechanism of activation of this kinase. As a longer term goal, he will attempt to trace the signal transduction pathways for NF-kB back to cell surface receptors.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
3F32CA073184-02S1
Application #
6203555
Study Section
Biological Sciences 2 (BIOL)
Program Officer
Lohrey, Nancy
Project Start
1998-01-01
Project End
Budget Start
1999-01-01
Budget End
2000-08-31
Support Year
2
Fiscal Year
2000
Total Cost
$29,555
Indirect Cost
Name
University of California San Diego
Department
Pharmacology
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093